导师简介

曹晓风,女,1965年生,中共党员,北京大学博士,中国科学院院士,美国科学院外籍院士,中国科学院遗传与发育生物学研究所研究员,中国科学院大学岗位教授,博士研究生导师。国家牧草产业技术体系岗位专家,国际植物表观遗传组学专家委员会委员,CAS-JIC联合研究中心共同主任,TWAS Membership Advisory Committee (MAC) in AGRICULTURAL SCIENCES,Current Opinion in Plant Biology编委,中国科学:生命科学主编,National Science Review编委,Plant Communications编委,中国侨联特聘专家委员会委员,中国女科技工作者协会副会长,国家盐碱地综合利用技术创新中心专家委员会副主任,中国科学院学术委员会委员,生命与健康领域专门委员会副主任,中国期刊协会第七届理事会副会长,中国遗传学会副理事长、秘书长。
一、研究方向
主要从事组蛋白甲基化修饰对植物发育和基因组稳定性的影响;植物耐逆机制与基因组适应性研究;优质饲草选育与盐碱地改良等研究。
二、科研项目与学术成果
以第一或通讯作者(含共同)在Cell、Science、Nature Genetics、Plant Cell、Nature Communications、Nature Plants、Molecular Plant、PNAS、Cell Research等国际知名学术刊物上发表论文100余篇。
(一)主持重要科研项目:
(1)国家自然科学基金项目,赋能药物创新的RNA基础研究发展趋势及战略分析,No. 92481001 , 2025-2029, 700万元。
(2)国家自然科学基金项目,水稻表观遗传重组自交系的创建与功能变异位点鉴定,No. 32330019 , 2024-2028, 232万元。
(3)中国科学院战略性先导科技专项,黑土地产能和质量提升的现代生物学技术,No. XDA28030000, 2021-2026, 5280.79万元。
(二)主要成果:
1、代表性期刊论文:
[1] Xiaofeng Cao(通讯作者). Inheritance of acquired adaptive cold tolerance in rice through DNA methylation. Cell, 2025, (SCI, IF=42.5,中科院一区).
[2] Xiaofeng Cao(通讯作者). Control of seed-to-seedling transition by an upstream open reading frame in ABSCISIC ACID DEFICIENT2. Proc Natl Acad Sci U S A. 2025, (SCI, IF=9.1,中科院一区).
[3] Xiaofeng Cao(通讯作者). Epigenetics in the modern era of crop improvements. Sci China Life Sci. 2025, (SCI, IF=9.5,中科院一区).
[4] Xiaofeng Cao(通讯作者). tRNA selectivity during ribosome-associated quality control regulates the critical sterility-inducing temperature in two-line hybrid rice. Proc Natl Acad Sci U S A. 2025, (SCI, IF=9.1,中科院一区).
[5] Xiaofeng Cao(通讯作者). The E3 ligase OsHel2 impedes readthrough of stalled mRNAs to regulate male fertility in thermosensitive genic male sterile rice. Plant Commun. 2025, (SCI, IF=11.6,中科院一区).
[6] Xiaofeng Cao(通讯作者). The Arabidopsis demethylase REF6 physically interacts with phyB to promote hypocotyl elongation under red light. Proc Natl Acad Sci U S A. 2025, (SCI, IF=9.1,中科院一区).
[7] Xiaofeng Cao(通讯作者). AtPRMT3-RPS2B promotes ribosome biogenesis and coordinates growth and cold adaptation trade-off. Nat Commun. 2024, (SCI, IF=15.7,中科院一区).
[8] Xiaofeng Cao(通讯作者). Dynamic root microbiome sustains soybean productivity under unbalanced fertilization. Nat Commun. 2024, (SCI, IF=15.7,中科院一区).
[9] Xiaofeng Cao(通讯作者). Light controls mesophyll-specific post-transcriptional splicing of photoregulatory genes by AtPRMT5. Proc Natl Acad Sci U S A. 2024, (SCI, IF=9.1,中科院一区).
[10] Xiaofeng Cao(通讯作者). Protein arginine methyltransferase 6 mediates antiviral immunity in plants. Cell Host Microbe. 2024, (SCI, IF=18.7,中科院一区).
[11] Xiaofeng Cao(通讯作者). Blocking miR528 function promotes tillering and regrowth in switchgrass. Plant Biotechnol J. 2024, (SCI, IF=10.5,中科院一区).
[12] Xiaofeng Cao(通讯作者). Impaired 2’,3’-cyclic phosphate tRNA repair causes thermo-sensitive genic male sterility in rice. Cell Res. 2024, (Cover story), (SCI, IF=25.9,中科院一区).
[13] Xiaofeng Cao(通讯作者). Acyl carrier protein OsMTACP2 confers rice cold tolerance at the booting stage. Plant Physiol. 2024, (SCI, IF=6.9,中科院一区).
[14] Xiaofeng Cao(通讯作者). Telomere-to-telomere genome of the allotetraploid legume Sesbania cannabina reveals transposon-driven subgenome divergence and mechanisms of alkaline stress tolerance. Sci China Life Sci. 2024, (SCI, IF=9.5,中科院一区).
[15] Xiaofeng Cao(通讯作者). Epigenetic and transcription factors synergistically promote the high temperature response in plants. Trends Biochem Sci. 2023, (SCI, IF=11,中科院一区).
[16] Xiaofeng Cao(通讯作者). A mitochondrial pentatricopeptide repeat protein enhances cold tolerance by modulating mitochondrial superoxide in rice. Nat Commun. 2023, (SCI, IF=15.7,中科院一区).
[17] Xiaofeng Cao(通讯作者). Efficient CRISPR/Cas9-mediated genome editing in sheepgrass (Leymus chinensis). J Integr Plant Biol. 2023, (SCI, IF=9.3,中科院一区).
[18] Xiaofeng Cao(通讯作者). Genome evolution and initial breeding of the Triticeae grass Leymus chinensis dominating the Eurasian Steppe. Proc Natl Acad Sci U S A. 2023, (SCI, IF=9.1,中科院一区).
[19] Xiaofeng Cao(通讯作者). Mobile ARGONAUTE 1d binds 22-nt miRNAs to generate phasiRNAs important for low-temperature male fertility in rice. Sci China Life Sci.2023, (Cover story), (SCI, IF=9.5,中科院一区).
[20] Xiaofeng Cao(通讯作者). Pseudouridylation of chloroplast ribosomal RNA contributes to low temperature acclimation in rice. New Phytol. 2022, (SCI, IF=8.1,中科院一区).
[21] Xiaofeng Cao(通讯作者). The Histone H3K27 Demethylase REF6/JMJ12 promotes thermomorphogenesis in Arabidopsis. Nat Sci Rev. 2022, (SCI, IF=17.1,中科院一区).
[22] Xiaofeng Cao(通讯作者). Reproductive tissue-specific translatome of a rice thermo-sensitive genic male sterile line. J Genet Genomics. 202, (SCI, IF=7.1,中科院一区).
[23] Xiaofeng Cao(通讯作者). Control of OsARF3a by OsKANADI1 contributes to lemma development in rice. Plant J. 2022, (SCI, IF=5.7,中科院一区).
[24] Xiaofeng Cao(通讯作者). Targeted DNA demethylation produces heritable epialleles in rice. Sci China Life Sci. 2022, (SCI, IF=9.5,中科院一区).
[25] Xiaofeng Cao(通讯作者). An engineered prime editor with enhanced editing efficiency in plants. Nat Biotech. 2022, (SCI, IF=41.7,中科院一区).
[26] Xiaofeng Cao(通讯作者). Precise editing of methylated cytosine in Arabidopsis thaliana using a human APOBEC3Bctd-Cas9 fusion. Sci China Life Sci. 2022, (SCI, IF=9.5,中科院一区).
[27] Xiaofeng Cao(通讯作者). CPSF30-L-mediated recognition of mRNA m6A modification controls alternative polyadenylation of nitrate signaling-related gene transcripts in Arabidopsis. Mol Plant. 2021, (SCI, IF=24.1,中科院一区).
[28] Xiaofeng Cao(通讯作者). Protein arginine methyltransferase 3 fine-tunes the assembly/disassembly of pre-ribosome to repress nucleolar stress by interacting with RPS2B in Arabidopsis. Mol Plant. 2021, (SCI, IF=24.1,中科院一区).
[29] Xiaofeng Cao(通讯作者). The rice histone methylation regulates hub species of the root. J Genet Genomics. 2021, (SCI, IF=7.1,中科院一区).
[30] Xiaofeng Cao(通讯作者). Extensive profiling of the expressions of tRNAs and tRNA derived fragments (tRFs) reveals the complexities of tRNA and tRF populations in plants. Sci China Life Sci. 2021, (SCI, IF=9.5,中科院一区).
2、会议报告:
[1] 中国遗传学会2025年全国学术研讨会,会议报告题目:组蛋白甲基化动态调控及水稻获得性遗传机理研究(2025)
[2] 2025 Keystone Symposia on Plant Epigenetics and Epigenome Engineering,会议报告题目:Epigenetics Regulation and Stress Memory(2025)
[3] The Plant & Animal Genome Conference,会议报告题目:tRNA repair controls thermo-sensitivemale sterility in rice(2025)
[4] 2025创新驱动发展大会暨白石山生命科学大会,会议报告题目:高等植物表观遗传调控及获得性遗传(2025)
[5] 新疆科技讲堂,会议报告题目:耐盐碱豆科饲草与盐碱地改良(2025)
[6] 2025国际草原与草业大会,会议报告题目:牧草育种与盐碱地改良(2025)
[7] The International Plant Molecular Biology (IPMB) Congress,会议报告题目:tRNA repair and recycling controls thermo-sensitive male fertility in rice(2024)
[8] Regulatory & Non-Coding RNAs Conference,会议报告题目:tRNA repair and recycling controls thermo-sensitive male fertility (TGMS) in rice(2024)
[9] AGBT Agricultural Meeting,会议报告题目:Eding of new forage grass for saline-alkali land improvement(2024)
[10] 第七届(2024)草业大会暨第十届(2024)苜蓿发展大会,会议报告题目:田菁育种与盐碱地改良(2024)
[11] 植物发育及分子生物学研讨会,会议报告题目:植物表观遗传调控机理与育种应用(2024)
[12] The 15th International Association for Plant Biotechnology Congress (IAPB 2023),会议报告题目:Inheritance of acquired adaptive cold tolerance in rice through DNA methylation(2023)
[13] the 33rd International Conference on Arabidopsis Research (ICAR2023) ,会议报告题目:Dynamic regulatory mechanism of H3K27me3 demethylase REF6 responding to environment(2023)
[14] 第十二届全国核糖核酸(RNA)学术讨论会,会议报告题目:非编码RNA调控在水稻温度响应过程中的机理研究(2023)
[15] 水稻种业发展院士专家高峰论坛,会议报告题目:表观遗传调控及水稻温敏雄性不育系机理研究(2019)
[16] 第四届全国玉米生物学学术讨论会,会议报告题目:Mechanisms and functions of dynamic histone methylation in higher plants(2019)
3、科研奖励与荣誉
[1] 美国杜邦青年科学家奖(排名第一),2008
[2] 中国科学院优秀导师奖,2008
[3] 中国科学院朱李月华优秀老师奖,2008
[4] 中国青年女科学家奖,2010
[5] 全国优秀科技工作者,2010
[6] 中国科学院优秀导师奖,2011
[7] 中国科学院院士,2015
[8] 北京市科学技术二等奖(第一完成人),2015
[9] 发展中国家科学院(TWAS)院士,2016
[10] 中央国家机关优秀共产党员,2016
[11] 中国科学院第五届“十大杰出妇女”,2017
[12] 中国植物生理与植物分子生物学学会CSPB杰出成就奖,2019
[13] 国家自然科学奖二等奖(第一完成人),2019
[14] 中国科学院朱李月华优秀老师奖,2020
[15] 美国科学院外籍院士,2020
[16] 中国科学院第六届“科苑名匠”,2025
4、知识产权
[1] 授权发明专利,一种田菁稳定高效加倍与快繁一体化的方法,ZL 202411860252.1,排名第一,2025
[2] 授权发明专利,一种与刺田菁耐盐性相关的Indel分子标记及其应用,ZL 202411839536.2,排名第二,2025
[3] 授权发明专利,选育或辅助选育茎瘤田菁的InDel 分子标记及其应用,ZL 202510020498.6,排名第一,2025
[4] 授权发明专利,一种羊草U6基因启动子proLcU6a的应用,ZL 202510018575.4,排名第一,2025
[5] 授权发明专利,一种羊草U3基因启动子proLcU3a的应用,ZL 202510018819.9,排名第一,2025
[6] 授权发明专利,水稻温敏两用不育系育性转育起点温度调控基因及其应用,ZL 20211 0544070.3,排名第一,2023
[7] 授权发明专利,miR528 的调控位点及其应用,ZL 201410423077.X,第一排名,2019
[8] 授权发明专利,水稻叶夹角的表观调控位点及其应用,ZL 201410038280.5,排名第一,2018
[9] 发表著作,《承续的魅力:令人着迷的表观遗传学》, 科学出版社, 2018-11, 第 1 作者
三、联系方式
E-mail:xfcao@genetics.ac.cn